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FSCH.SE186148

Evaluation of Oxidative Stress Status in Aged Human in Relation to some Diseases
Ismail Salih Kakey 
Department of Biology, Faculty of Sceince and Health, Koya University
http://koyauniversity.org

Abstract: The current study included 60 aged persons (30 men’s and 30 women’s) at age ranges of (40-80) years, and 30 young healthy persons (15 men and 15 women) as control groups. The samples were collected in the Educational Hospital of Shied Doctor Khalid in Koya city and nursing home in Erbil Governorate. Blood sample were collected from subject and control persons. Then the serum separated and for biochemical analysis. The fully automated ELISA system was used to determination of oxidative and antioxidant parameters.
According to the results of the current study, the levels of oxidative stress parameter increased, and the levels of antioxidant parameters were decreased with aging. The data analysis showed significant (p<0.05) elevation of malondialdehyde (MDA) in both aged groups of healthy and nonhealthy males and females, and its level is higher in smoker groups male than in nonsmoker one. And the level of protein carbonyl group was significantly (p<0.05) in both aged groups of nonhealthy and healthy males and females, and its level is higher in smoker aged group men than in nonsmoker groups.
The result revealed that the level of superoxide dismutase (SOD) was significantly (p<0.05) decreased in both aged group of healthy and nonhealthy males and females and the level of superoxide dismutase is lower in smoker aged group men than in nonsmoker one. Also, the level of total antioxidant capacity is lower in smoker aged men than in nonsmoker one.

KeywordsAge related disease, Aging, Oxidative stress.

Date: 19/11/2018
Place: Department of Biology/ Hall 14
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Caroline Yousif Daniel,
Apr 14, 2019, 2:41 AM