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Qualitative and Quantitative Identification of DNA Methylation Changes in Blood of the Breast Cancer patients

Harem Othman Smail 
Department of Biology, Faculty of Sceince and Health, Koya University

Abstract: Recently , DNA methylation is a main epigenetic modification in human breast cancer are discovered as a promising biomarker in early detection of breast cancer.In total, 30 cases of in women breast cancer and 8 cases of healthy blood were studied. DNA extracted from blood samples, and bisulfate conversion reaction was used to unmethylated conversion cytosine to Uralic and ethylated cytosine not affected. Based on the sequence data analysis by BiQ Analyzer software the results for
ESR2 are (4.16 %)from CPG from the healthy sample was methylated while (12.39%) CPG from cancer sample was methylated, and Also unmethylated CPG were difference between healthy and cancer sample.

breast cancer
suppressor gene
DNA methylation

Date: 13/11/2017
Place: Department of Biology/ Hall 8
Caroline Yousif Daniel,
Jan 12, 2018, 10:43 AM